Modaplex Solution
BRIDGING THE GAP BETWEEN qPCR AND NGS





- Quantitative PCR (qPCR) is fast and sensitive, but only provides information on a few genetic targets simultaneously
- Next Generation Sequencing (NGS) can detect an almost unlimited number of targets, but is time-consuming and expensive
To overcome these limitations and fill the diagnostic gap, we present the Modaplex technology. This proprietary platform enables the quantification of up to 50 DNA and/or RNA markers per sample within 3.5 hours.
Features
Simplify The complexity in molecular diagnostics
Quantify all types of genetic alterations
Advantages
Quantify up to 50 targets per well
Analyze both DNA & RNA
- Mutations
- Copy Number Variations
- Gene Expression
- Gene Fusions
- Micro RNAs
- Polysomy
- DNA Methylation
- Fragment Length Polymorphisms
- Splicing Variants
Compatible with various sample types
- Plasma, serum, and whole blood
- Liquid biopsies
- Stool
- Tissue
- Formalin-fixed, paraffin-embedded tissue (FFPE)
- Cell lines, cell cultures
- Fungi, bacteria, and viruses
Obtain same-day results
Advantages
Results within 3.5 hours
Quick data analysis
Run different assays simultaneously
Integrates easily into your workflow
Advantages
Workflow as simple as PCR
Scalable and flexible
Analyze challenging samples
Technology
Unique Method of Multiplex Quantification


- Polymerase chain reaction (PCR) and
- Simultaneous capillary electrophoresis (CE).
During a Modaplex run, the genetic targets of interest are amplified in a PCR reaction. While the PCR reaction continues undisturbed, the amplified DNA fragments are electro-kinetically injected into a capillary gel. In this gel, the DNA fragments are separated by size and quantitatively detected. This process is repeated after each PCR cycle. In this way, real-time data is generated, thus enabling the simultaneous quantification of up to 50 targets.
Modaplex workflow
Same-day results through a workflow as simple as PCR

PCR set-up

Modaplex run

Data analysis
3.5 hrs
Results are evaluated with the Modaplex Result Analyzer (Moda-RA) software. Moda-RA provides automatic import of acquired data from the Modaplex device, along with the analysis and summary of results in a comprehensive report.
Assays & Services
Current Portfolio & Custom Development
Available Modaplex Assays
- Modaplex MSI Analysis Kit
- Modaplex POLE/POLD1 Mutation Analysis Kit
More assays coming soon.

Custom Test Development
- Companion diagnostics for therapy monitoring and patient stratification
- Molecular diagnostics
- Food safety and food quality
- Pathogen detection (bacteria, viruses, parasites or fungi)
- And many more
If you are interested in the Modaplex for your own test development or study, please contact us or find out more at https://custom-solutions.biotype.de.
Assays & Services
Enjoy our complementary product offer
Available Modaplex Assays
- Modaplex MSI Analysis Kit
- Modaplex POLE/POLD1 Mutation Analysis Kit
More assays coming soon.

Custom Test Development
- Companion diagnostics for therapy monitoring and patient stratification
- Molecular diagnostics
- Food safety and food quality
- Pathogen detection (bacteria, viruses, parasites or fungi)
- And many more
If you are interested in the Modaplex for your own test development or study, please contact us or find out more at https://custom-solutions.biotype.de.
Contact
Biotype GmbH
Moritzburger Weg 67
01109 Dresden
Germany
Mail: modaplex@biotype.de
Tel: +49 351 8838 400