Modaplex

Simplify the Complexity in Molecular Diagnostics

Modaplex Solution

BRIDGING THE GAP BETWEEN qPCR AND NGS

There are several limitations to current diagnostic technologies when many genetic targets from multiple samples have to be analyzed in a short period of time:

  • Quantitative PCR (qPCR) is fast and sensitive, but only provides information on a few genetic targets simultaneously
  • Next Generation Sequencing (NGS) can detect an almost unlimited number of targets, but is time-consuming and expensive

To overcome these limitations and fill the diagnostic gap, we present the Modaplex technology. This proprietary platform enables the quantification of up to 2,000 DNA and RNA targets within 3.5 hours.

Features

Simplify The complexity in molecular diagnostics

Quantify all types of genetic alterations

Advantages

Quantify up to 50 targets per well

With the Modaplex you can perform multiplex quantification, ranging from single-target quantification to up to 50 targets per well.

Analyze both DNA & RNA

  • Mutations
  • Copy Number Variations
  • Gene Expression
  • Gene Fusions
  • Micro RNAs
  • Polysomy
  • DNA Methylation
  • Fragment Length Polymorphisms
  • Splicing Variants

Compatible with various sample types

  • Plasma, serum, and whole blood
  • Liquid biopsies
  • Stool
  • Tissue
  • Formalin-fixed, paraffin-embedded tissue (FFPE)
  • Cell lines, cell cultures
  • Fungi, bacteria, and viruses

Obtain same-day results

Advantages

Results within 3.5 hours

In just 3.5 hours, the complete workflow – including PCR set-up, Modaplex run, and data analysis – is completed.

Quick data analysis

Spend less time on data analysis with the intuitive Modaplex Result Analyzer (Moda-RA) software.

Run different assays simultaneously

Modaplex helps you to avoid sample-batching via a PCR protocol that is identical for all assays and combinations of assays.

Integrates easily into your workflow

Advantages

Workflow as simple as PCR

Benefit from a load-and-walk-away workflow with little hands-on time.

Scalable and flexible

Measure more parameters per sample or multiple samples simultaneously. Any combination of samples and markers can be analyzed for up to 48 wells.

Analyze challenging samples

With the Modaplex, you obtain reliable results even from highly fragmented sample material (e.g. FFPE) as well as from low sample inputs (≤2ng).

Technology

Unique Method of Multiplex Quantification

The Modaplex platform provides a novel real-time quantification procedure through the unique combination of two traditional methods in an automated run:

  • Polymerase chain reaction (PCR) and
  • Simultaneous capillary electrophoresis (CE).

During a Modaplex run, the genetic targets of interest are amplified in a PCR reaction. While the PCR reaction continues undisturbed, the amplified DNA fragments are electro-kinetically injected into a capillary gel. In this gel, the DNA fragments are separated by size and quantitatively detected. This process is repeated after each PCR cycle. In this way, real-time data is generated, thus enabling the simultaneous quantification of up to 50 targets.

Modaplex workflow

Same-day results through a workflow as simple as PCR

PCR set-up

15 min

9

Modaplex run

~ 3 hrs

9

Data analysis

15 min

3.5 hrs

The Modaplex load-and-walk-away workflow is identical for all tests and combinations of tests. The workflow comprises three steps: PCR set-up, Modaplex run, and data analysis.

Results are evaluated with the Modaplex Result Analyzer (Moda-RA) software. Moda-RA provides automatic import of acquired data from the Modaplex device, along with the analysis and summary of results in a comprehensive report.

Assays & Services

Current Portfolio & Custom Development

Available Modaplex Assays

Discover the wide portfolio of our Modaplex Analysis Kits: 

More assays coming soon.

Custom Test Development

Our customized assay development covers your specific set of biomarkers and converts your ideas into a marketable product – either RUO or CE-IVD. The Modaplex technology is the method of choice for: 

  • Companion diagnostics for therapy monitoring and patient stratification
  • Molecular diagnostics
  • Food safety and food quality
  • Pathogen detection (bacteria, viruses, parasites or fungi)
  • And many more

If you are interested in the Modaplex for your own test development or study, please contact us or find out more at https://custom-solutions.biotype.de.

Assays & Services

Enjoy our complementary product offer

Available Modaplex Assays

Discover the wide portfolio of our Modaplex Analysis Kits: 

More assays coming soon.

Custom Test Development

Our customized assay development covers your specific set of biomarkers and converts your ideas into a marketable product – either RUO or CE-IVD. The Modaplex technology is the method of choice for: 

  • Companion diagnostics for therapy monitoring and patient stratification
  • Molecular diagnostics
  • Food safety and food quality
  • Pathogen detection (bacteria, viruses, parasites or fungi)
  • And many more

If you are interested in the Modaplex for your own test development or study, please contact us or find out more at https://custom-solutions.biotype.de.

080207

Contact

Biotype GmbH

Moritzburger Weg 67
D-01109 Dresden
Germany

Mail: modaplex@biotype.de

Tel: +49 351 8838 400

© 2019 Biotype GmbH