Modaplex KNB Assays
When either KRAS, NRAS, or BRAF is mutated, the cellular signaling is altered, leading to several abnormalities including cancer.
The Modaplex portfolio has been expanded with the Modaplex KRAS, NRAS, and BRAF Mutation Analysis Kits for research use only. In one Modaplex run, 30 mutations in KRAS, NRAS, and BRAF genes can be detected and differentiated in three wells simultaneously.
The Modaplex KNB Analysis Kits are:
- Developed under ISO 9001:2015 and the FDA’s Design Control Guidance for medical device manufacturers
- Standardized kits with a comprehensive control concept
- Ready-to-use assays with a simple and efficient workflow
NRAS is an oncogene encoding for the N-Ras protein. It is involved in regulating cell division (by converting GTP to GDP) and belongs to the RAS/MAPK pathway regulating cell proliferation, cell differentiation, cellular migration, and apoptosis .
BRAF is a proto-oncogene encoding for a serine/threonine protein kinase B-Raf. It is involved in signal transduction and belongs to the RAS/MAPK pathway regulating cell proliferation, cell differentiation, cellular migration, and apoptosis .
 N. Irahara et al, “NRAS Mutations Are Rare in Colorectal Cancer”, Diagn Mol Patho, vol. 19, no. 3, pp: 157–163, 2010.
 W.Q. Li et al, “ BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status”, Molecular Cancer, vol. 5 no. 2, 2006.